AI Article Synopsis
- This study compares the effectiveness and outcomes of two surgical methods (en bloc resection and intralesional excision) for re-secting giant cell tumors in the spine.
- The research, conducted from 2005 to 2021, included 22 patients and found that en bloc resection resulted in significantly better local tumor control over time, with a recurrence rate of only 10% after five years compared to 20% for intralesional excision.
- However, en bloc resection was associated with higher complications, highlighting the trade-off between better tumor control and increased risk during surgery.
Article Abstract
Objective: Re-resection of spinal giant cell tumors is an exceedingly difficult procedure. Moreover, the prognosis of patients with en bloc resection or intralesional excision for re-resection has rarely been reported. This study aimed to compare the prognostic value of en bloc resection with that of intralesional excision in patients undergoing re-resection for giant cell tumors of the spine.
Methods: This retrospective analysis evaluated patients who underwent revision surgeries for relapse of giant cell tumors of the spine at our center between January 2005 and January 2021. Local progression-free survival represents the duration between en bloc resection or intralesional excision and tumor recurrence. Neurological recovery, survival rates, local control, and complications were evaluated. The Kaplan-Meier estimator was used for survival analysis.
Results: A total of 22 patients (nine men and 13 women) with a mean age of 34.1 (range 19-63) years were included. Significant statistical differences were found in the local tumor recurrence rate between patients treated with en bloc resection and those treated with intralesional excision (p < 0.05). The 5- and 10-year local progression-free survival rates were both 90% in the en bloc resection group, while in the intralesional excision group, the 5-year local progression-free survival rate was 80% with a 10-year rate of 45.7%. The en bloc resection group had a lower local tumor recurrence rate than that of the intralesional excision group (p < 0.05), but the former had a higher rate of complications (p = 0.015).
Conclusions: This study revealed a low local recurrence rate in patients who underwent en bloc resection for giant cell tumors, while the perioperative complication rate was high.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925495 | PMC |
| http://dx.doi.org/10.1111/os.13999 | DOI Listing |
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