AI Article Synopsis
- The study aims to investigate the link between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) in extremely preterm infants at 24 months of age.
- Researchers analyzed data from two neonatal units, focusing on infants born between 23 and 28 weeks gestation, assessing outcomes related to maternal hypertension and small-for-gestational-age (SGA) status.
- The findings revealed that infants exposed to maternal hypertension had significantly higher odds of developing any NDI and that the risk increased even more when combined with SGA conditions.
Article Abstract
Objective: To examine the association between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) at 24 months post-menstrual age in extremely preterm infants.
Study Design: Using data from two tertiary neonatal units (2011-2017) for infants born at 23 + 0 to 28 + 6 weeks, we investigated outcomes of NDI related to maternal hypertension and small-for-gestational-age (SGA) status.
Results: Of 1019 pre-term infants, 647 had complete data and were included in the analysis. Ninety-six (15%) had maternal hypertension exposure; 25 (4%) were also SGA. Infants with maternal hypertension showed a higher odds of any NDI (aOR: 2.29, 95% CI = 1.36-3.87) and significant NDI (aOR: 2.01, 95% CI = 1.02-3.95). The combination of hypertension and SGA further elevated this risk (aOR for any NDI: 4.88, 95% CI = 1.80-13.22; significant NDI: 6.91, 95% CI = 2.50-19.12).
Conclusion: Maternal hypertension during pregnancy elevates the risk of NDI in extremely preterm infants, more so when combined with SGA.
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| http://dx.doi.org/10.1038/s41372-024-01886-7 | DOI Listing |
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