The quality of data in charge detection mass spectrometry depends on accurate determination of ion charge. While the method of selective temporal overview of resonant ions (STORI) has proven to be highly enabling for determining the charge of ions that survive for variable amounts of time, it assumes that the ion frequency exactly matches the frequency being used in the calculation. Any mismatches result in low charge estimates. To address this, the misSTORI method was developed to correct these discrepancies. This can significantly reduce the charge measurement errors for samples with unstable masses. As an example, the misSTORI approach can eliminate a 5.7% charge determination error for a VP3-only AAV capsid that shifts 25 ppm in mass.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990768 | PMC |
| http://dx.doi.org/10.1021/jasms.3c00435 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016-2021).
BMC Infect Dis
January 2025
Bureau de L'Organisation Mondiale de La Santé (OMS), Niamey, Niger.
Background: Recently, a total of 74 circulating vaccine-derived poliovirus (cVDPV) outbreaks were detected in 39 countries, with 672 confirmed Acute Flaccid Paralysis (AFP) cases identified in 27 countries. Despite progress, Niger experienced cVDPV outbreaks in 2018, highlighting the importance of maintaining AFP surveillance as a tool for polio eradication. This analysis aims to comprehensively assess AFP surveillance trends, patterns, and challenges in Niger, offering insights for public health initiatives in conflict-affected contexts.
View Article and Find Full Text PDFFabrication of TeNT/TeO heterojunction based sensor for ultrasensitive detection of NO.
J Hazard Mater
January 2025
School of Integrated Circuits, Dalian University of Technology, Dalian, Liaoning 116024, China. Electronic address:
Tellurium nanotubes (TeNT) heterojunction with Tellurium oxide (TeO) were prepared by in situ oxidation at elevated temperatures in air. The chemiresistive type NO sensor was then fabricated by depositing the synthesized TeNT/TeO on the integrated gold electrodes. The response of the TeNT/TeO based sensor to 600 ppb NO was 38.
View Article and Find Full Text PDFSeizure detection via reservoir computing in MoS-based charge trap memory devices.
Sci Adv
January 2025
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano and IU.NET, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Neurological disorders are a substantial global health burden, affecting millions of people worldwide. A key challenge in developing effective treatments and preventive measures is the realization of low-power wearable systems with early detection capabilities. Traditional strategies rely on machine learning algorithms, but their computational demands often exceed what miniaturized systems can provide.
View Article and Find Full Text PDF3D active-matrix multimodal sensor arrays for independent detection of pressure and temperature.
Sci Adv
January 2025
Department of Convergence IT Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Pohang 37673, Republic of Korea.
Pressure and temperature sensing simultaneously and independently is crucial for creating electronic skin that replicates complex sensory functions of human skin. Thin-film transistor (TFT) arrays with sensors have enabled cross-talk-free spatial sensing. However, the thermal dependence of charge transport in semiconductors has resulted in interference between thermal and pressure stimuli.
View Article and Find Full Text PDFMachine vision model for drip leakage detection of pipeline.
PLoS One
January 2025
School of Power and Mechanical Engineering, Wuhan University, Wuhan, China.
The prevailing trend in industrial equipment development is integration, with pipelines as the lifeline connecting system components. Given the often harsh conditions of these industrial equipment pipelines, leakage is a common occurrence that can disrupt normal operations and, in severe cases, lead to safety accidents. Early detection of even minor drips at the onset of leakage can enable timely maintenance measures, preventing more significant leaks and halting the escalation of pipeline failures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!