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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Nat Metab
February 2024
Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes mitochondrial fragmentation in inguinal white adipocytes from male mice, leading to reduced oxidative capacity by a process dependent on the small GTPase RalA. RalA expression and activity are increased in white adipocytes after HFD.
View Article and Find Full Text PDFA RalA between high-fat diet and mitochondrial shape.
Nat Metab
February 2024
Department of Biology, University of Padova, Padova, Italy.
Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance, and fatty liver disease. Here we report that mitochondria undergo fragmentation and reduced oxidative capacity specifically in inguinal white adipose tissue after feeding mice high fat diet (HFD) by a process dependent on the small GTPase RalA. RalA expression and activity are increased in white adipocytes from mice fed HFD.
View Article and Find Full Text PDFTargeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control.
Sci Adv
April 2019
State Key Laboratory of Pharmaceutical Biotechnology, Department of Endocrinology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University, Nanjing 210061, China.
How insulin stimulates postprandial uptake of glucose and long-chain fatty acids (LCFAs) into skeletal muscle and the mechanisms by which these events are dampened in diet-induced obesity are incompletely understood. Here, we show that RalGAPα1 is a critical regulator of muscle insulin action and governs both glucose and lipid homeostasis. A high-fat diet increased RalGAPα1 protein but decreased its insulin-responsive Thr-phosphorylation in skeletal muscle.
View Article and Find Full Text PDFFDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation.
Eur J Nucl Med Mol Imaging
June 2019
Nuclear Medicine Department, Bichat-Claude Bernard Hospital, AP-HP, Paris, France.
Purpose: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke. Indeed, silent AF is frequently identified in unexplained ischemic stroke. F-FDG-PET/CT is a powerful tool for assessing myocardial metabolic shift and inflammation, both potentially at stake in AF.
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