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Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum. | LitMetric

Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum.

Carbohydr Polym

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, Jiangsu Province, China; Department of Pharmaceutical Laboratory, Anhui Sunhere Pharmaceutical Excipients Co., Ltd., Huainan, 232000, Anhui Province, China; Department of Research, Biosan Biotech Co., Ltd, Lishui, 323000, Zhejiang Province, China. Electronic address:

Published: April 2024

AI Article Synopsis

  • Fusobacterium nucleatum is linked to the development and worse outcomes of colorectal cancer, making it a significant target for treatment.
  • A probiotic strain, Enterococcus faecium (EF47), has been found to effectively combat F. nucleatum by producing organic acids and bacteriocins, but its effectiveness is reduced in the harsh environment of the digestive tract.
  • To improve delivery to the colon, a specially designed coating (hyaluronic acid-inulin) protects EF47 during digestion and promotes its growth in the colon, enhancing its adhesion to tumor tissues and potentially improving treatment for colorectal cancer.

Article Abstract

The abundance of Fusobacterium nucleatum (F. nucleatum) is highly associated with the development and poor prognosis of colorectal cancer (CRC), which is regarded as a promising target for CRC. However, until now, the novel strategy to clear F. nucleatum in the colon and CRC has not been well proposed. Herein, a probiotic strain Enterococcus faecium (E. faecium, EF47) is verified to secrete various organic acids and bacteriocins to exert superior antimicrobial activity towards F. nucleatum. However, the oral delivery of EF47 is affected by the complex digestive tract environment, so we design the hyaluronic acid-inulin (HA-IN) coated EF47 for colon-targeted delivery to fight F. nucleatum. IN can protect EF47 from the harsh gastrointestinal tract environment and is degraded specifically in the colon, acting as prebiotics to further promote the proliferation of EF47. The exposed HA can also enhance the targeting effect to the tumor area via the interaction with the CD44 receptor on the tumor cells, which is confirmed to increase the adhesive ability in tumor tissues and inhibit the growth of F. nucleatum. Therefore, this colon-targeted delivery system provides a novel platform to realize high-activity and adhesive delivery of probiotics to assist the therapeutic efficiency of CRC.

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Source
http://dx.doi.org/10.1016/j.carbpol.2024.121797DOI Listing

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