AI Article Synopsis
- Intranasal drug delivery is a noninvasive and effective method for treating various diseases, including those affecting the nervous system.
- Despite extensive reviews on its applications, there's a lack of a comprehensive analysis covering recent advancements and future directions in this field.
- This review presents a scientometric analysis of intranasal drug delivery, highlighting challenges, mechanisms of drug entry and elimination, suitable drugs and dosage forms, as well as diseases that can benefit from this approach, to inspire further research.
Article Abstract
Intranasal drug delivery is as a noninvasive and efficient approach extensively utilized for treating the local, central nervous system, and systemic diseases. Despite numerous reviews delving into the application of intranasal drug delivery across biomedical fields, a comprehensive analysis of advancements and future perspectives remains elusive. This review elucidates the research progress of intranasal drug delivery through a scientometric analysis. It scrutinizes several challenges to bolster research in this domain, encompassing a thorough exploration of entry and elimination mechanisms specific to intranasal delivery, the identification of drugs compatible with the nasal cavity, the selection of dosage forms to surmount limited drug-loading capacity and poor solubility, and the identification of diseases amenable to the intranasal delivery strategy. Overall, this review furnishes a perspective aimed at galvanizing future research and development concerning intranasal drug delivery.
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| http://dx.doi.org/10.1016/j.jconrel.2024.01.053 | DOI Listing |
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