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Association of prenatal chlorpyrifos exposure with sexually dimorphic differences in anogenital distance among Thai farmworker children. | LitMetric

AI Article Synopsis

  • Organophosphate (OP) insecticides, like chlorpyrifos, are widely used and have been linked to negative health effects during pregnancy and in children.
  • Researchers studied the impact of prenatal exposure to chlorpyrifos on anogenital distance (AGD), a marker of reproductive health, in a group of pregnant farmworkers in Thailand.
  • The study found that while there was some reduction in AGD associated with higher levels of chlorpyrifos exposure, the results were modest and not statistically significant, particularly by the time the children reached 12 months of age.

Article Abstract

Organophosphate (OP) insecticides are some of the most abundantly used insecticides, and prenatal exposures have been linked to adverse maternal and child health outcomes. Anogenital distance (AGD) has emerged as an early marker of androgen activity, and later reproductive outcomes, that is sensitive to alteration by environmental chemicals. Here, we examined associations between prenatal exposure to chlorpyrifos, an OP insecticide, with AGD. Pregnant farmworkers were enrolled in the Study of Asian Women and their Offspring's Development and Environmental Exposures (SAWASDEE; N = 104) between 2017 and 2019 in Northern Thailand. Concentrations of 3,5,6-trichloro-2-pyridinol (TCPy), a specific metabolite of chlorpyrifos, were measured in composited urine samples obtained from each trimester of pregnancy. AGD was measured at 12 months of age. Sex-specific adjusted linear regression models were used to examine associations between average and trimester-specific TCPy levels and AGD. In adjusted models for females and males, increasing TCPy was consistently associated with a modest, non-significant reduction in AGD. Across both strata of sex, associations were greatest in magnitude for trimester 3 (females: β = -2.17, 95 % confidence interval (CI) = -4.99, 0.66; males: β = -3.02, 95 % CI = -6.39, 0.35). In the SAWASDEE study, prenatal chlorpyrifos exposure was not strongly associated with AGD at 12 months of age.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11023773PMC
http://dx.doi.org/10.1016/j.envres.2024.118325DOI Listing

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