AI Article Synopsis
- Epileptic seizures are often the first sign of glioma, but the exact link between gliomas and seizures remains unclear beyond physical tumor effects.
- A study reviewed 320 glioma patients to identify seizure biomarkers using logistic regression, focusing on their treatment from January 2019 to July 2022.
- The findings revealed that the IDH1 R132H mutation is a significant risk factor for seizures in lower-grade glioma patients and is associated with better seizure control when combined with normal ATRX expression.
Article Abstract
Epileptic seizures are frequently the first symptom in glioma patients. However, the causal relationship between glioma and epilepsy is not yet fully understood, as it cannot be explained solely by tumor mass effect or peritumoral factors. In this study, we retrospectively enrolled 320 patients with grade 2-4 glioma who received treatment between January 2019 and July 2022, and explored the biomarkers of seizure occurrence and seizure outcome prediction using univariate and multivariate logistic regression analyses. Our results showed that IDH1 R132H mutation was an independent risk factor for seizure occurrence in lower-grade glioma (LGG) patients (OR = 4.915, 95%CI = 1.713 - 14.103, P = 0.003). Additionally, IDH1 R132H mutation predicted higher seizure-free ratios in LGG patients with intact ATRX expression (OR = 6.793, 95%CI = 1.217 - 37.923, P = 0.029) one year after diagnosis. Therefore, our findings suggest that IDH1 mutation can predict seizure occurrence and control in LGG patients, providing further insights into the relationship between glioma and epilepsy.
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| http://dx.doi.org/10.1016/j.prp.2024.155165 | DOI Listing |
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