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A single-center retrospective study of the molecular epidemiological characteristics of different infections in northern China.
J Thorac Dis
November 2024
Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin, China.
Background: ( ) is an opportunistic pathogen that can cause multiple life-threatening infections. Recently, there has been an upward trend in carbapenem-resistant infections in China. This epidemiological trend needs to be examined to enable better disease control.
View Article and Find Full Text PDFPrevalence, Risk Factors and Antibiotic Resistance of Extended-Spectrum Beta-Lactamase-Producing in Children Hospitalized with Urinary Tract Infection at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Children (Basel)
October 2024
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Article Synopsis
- The study investigated the prevalence and risk factors of extended-spectrum beta-lactamase (ESBL)-producing bacteria in children hospitalized for urinary tract infections (UTIs) at a hospital in Saudi Arabia from 2018 to 2022.
- Out of 242 urine samples analyzed, 20.7% of the isolates were found to be ESBL producers, with previous antibiotic usage and recurrent UTIs identified as significant risk factors.
- The ESBL-producing bacteria showed high resistance rates to ampicillin and third-generation cephalosporins, but were universally sensitive to meropenem, highlighting the need for better antibiotic management in high-risk pediatric cases.
Characterization of a novel multi-resistant Pseudomonas juntendi strain from China with chromosomal bla and a megaplasmid coharboring bla and bla.
BMC Genomics
August 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, National Medical Center for Infectious Diseases, Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou City, 310003, China.
Article Synopsis
- - A new strain of
- Pseudomonas juntendi
- (strain L4236), an opportunistic pathogen, was isolated from human feces and identified as multidrug resistant, though it remained sensitive to the antibiotic amikacin.
- - This strain was analyzed using various genomic and phenotypic methods, revealing a large genetic element known as a megaplasmid that carries resistance genes, including a novel variant.
- - The findings suggest that antimicrobial use may have contributed to the development of drug resistance in this strain, indicating a need for further research on its implications in clinical settings.
Some virulence genes are associated with antibiotic susceptibility in Enterobacter cloacae complex.
BMC Infect Dis
July 2024
Departement of Medical Microbiology (Bacteriology & Virology), Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Background: Enterobacter cloacae complex (ECC) including different species are isolated from different human clinical samples. ECC is armed by many different virulence genes (VGs) and they were also classified among ESKAPE group by WHO recently. The present study was designed to find probable association between VGs and antibiotic susceptibility in different ECC species.
View Article and Find Full Text PDFEvolution of Under the Pressure of Carbapenems and Ceftazidime/Avibactam in a Patient With Persistent Bacteremia Caused by .
J Korean Med Sci
July 2024
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
A 30-year-old Korean man with myelodysplastic syndrome admitted hospital due to undifferentiated fever and recurrent skin lesions. He received combination therapy with high doses of meropenem, tigecycline and amikacin, yielding carbapenem resistant (CRKP) harboring carbapenemase (KPC)-2 from blood cultures on hospital day (HD) 23. Ceftazidime/avibactam was started at HD 37 and CRKP was eradicated from blood cultures after 5 days.
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