AI Article Synopsis
- Bariatric surgery (BS), particularly Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), may lead to bone loss and an increased risk of vertebral fractures.
- In a study of 80 patients, the prevalence of morphometric vertebral fractures (MVF) was found to be 17.5%, with no significant difference between the RYGB and SG groups despite differences in some bone markers.
- The RYGB group exhibited lower bone mineral density (BMD) in various regions compared to SG, indicating potential long-term bone health concerns post-surgery.
Article Abstract
Background: Bariatric surgery (BS) can lead to bone loss and an increased fracture risk.
Methods: To determine the morphometric vertebral fracture (MVF) prevalence, and its relationship with bone mineral density (BMD), and biomarker's turnover after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), we analyzed post-surgery X-rays of the spine in 80 patients (88% female, 51% RYGB, age 41.2 [6.8] years) from 117 participants' retrospective cohort (1-2 years, >2 and <5 years, and >5 years). We still analyzed body composition and BMD by dual-energy X-ray absorptiometry and bone parameters.
Results: MVF prevalence was 17.5% (14/80), with no statistical difference between groups (p = 0.210). RYGB group had a higher prevalence of secondary hyperparathyroidism (SHPT) (PTH ≥ 65 pg/ml; 18.4% vs 7.8%, respectively, p = 0.04), PTH (61.3 vs 49.5 pg/ml, p = 0.001), CTX (0.766 [0.29] ng/ml vs 0.453 [0.30] ng/ml, p = 0.037), and AP (101.3 [62.4] U/L vs 123.9 [60.9] U/L, p = 0.027) than the SG group. Up to 5 years postoperatively, RYGB had a lower total (1.200 [0.087] vs 1.236 [0.100] g/cm, p = 0.02), femoral neck (1.034 [0.110] vs 1.267 [0.105], p = 0.005), and total femur BMD (1.256 [0.155] vs 1.323 [0.167], p = 0.002) than SG group. We found no statistically significant difference between the MFV (+) and MVF (-) groups regarding age, sex, BMI, surgery time, BMD, or bone and metabolic parameters, including leptin.
Conclusion: We found a high prevalence of MVF after BS with no differences between RYGB and SG.
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| http://dx.doi.org/10.1007/s11695-023-07049-5 | DOI Listing |
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