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Sun Exposure and Type 2 Diabetes Mellitus: A Prospective Follow-up Cohort Study from Southern Sweden.
Anticancer Res
January 2025
Endocrinology, Clinical Sciences, Lund University Hospital, Lund University, Lund, Sweden.
Background/aim: An inverse association exists between type 2 diabetes mellitus (T2DM) and both plasma vitamin D levels and sun exposure, but vitamin D supplementation does not reduce the incidence. We sought to assess whether there is a dose-dependency in the association between sun exposure and T2DM.
Patients And Methods: The melanoma in Southern Sweden (MISS) cohort is comprised of one thousand women without cancer from age groups between 25 and 64, drawn from the Southern Swedish Population Registry of 1990 by random selection.
A Narrative Review of the Role of Estrogen (Receptors) in Melanoma.
Int J Mol Sci
June 2024
Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
In this narrative review, we attempt to provide an overview of the evidence regarding the role of estrogen (receptors) in cutaneous melanoma (CM). We reviewed 68 studies and 4 systematic reviews and meta-analyses published from 2002 up to and including 2022. The prevailing presence of estrogen receptor β (ERβ) instead of estrogen receptor α (ERα) in CM is notable, with ERβ potentially playing a protective role and being less frequently detected in progressive cases.
View Article and Find Full Text PDFMelanoma and menarche: Exploring the hormonal impact in pediatric cases.
Pediatr Dermatol
January 2024
Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.
Reproductive factors, hormone use, and incidence of melanoma in a cohort of US Radiologic Technologists.
Hum Reprod
May 2022
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA.
Study Question: Are reproductive factors and exogenous hormone use associated with incidence of cutaneous melanoma while accounting for ultraviolet radiation (UVR) exposure across different life periods and sun sensitivity factors?
Summary Answer: Earlier age at menarche and late age at first birth, but not other estrogen-related factors were associated with an increased incidence rate of melanoma, with higher risks observed for earlier age at menarche and light hair color at age 15 years.
What Is Known Already: Although estrogens have been recognized as photosensitizing, previous studies have reported inconsistent findings for the association of melanoma with estrogen-related factors. Most have not collected detailed skin cancer risk factors and have not thoroughly investigated effect modification by ambient UVR and sun sensitivity.
Fertility drugs and incidence of thyroid cancer in a Danish nationwide cohort of 146 024 infertile women.
Hum Reprod
April 2022
Lifestyle, Reproduction and Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark.
Study Question: Do fertility drugs increase the risk of thyroid cancer among infertile women?
Summary Answer: The use of most types of fertility drugs was not associated with an increased risk of thyroid cancer.
What Is Known Already: The incidence of thyroid cancer is higher for women than men, especially during reproductive years, indicating that reproductive hormones may be involved in the development of thyroid cancer. Only a few previous studies have examined the association between the use of fertility drugs and incidence of thyroid cancer and the results are inconclusive.
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