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Nervous system in colorectal cancer.
Cancer Lett
December 2024
Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, China. Electronic address:
A malignant tumor is a complex systemic disease involving the nervous system, which regulates nerve signals. Cancer neuroscience is a field that explores the interactions between tumors and the nervous system. The gastrointestinal tract is a typical peripheral organ with abundant neuroregulation and is regulated by the peripheral, enteric, and central nervous systems (PNS, ENS, and CNS, respectively).
View Article and Find Full Text PDFCARVEDILOL IN PATIENTS WITH UNCONTROLLED AND RESISTANT ARTERIAL HYPERTENSION.
Georgian Med News
October 2024
2Department of Cardiology, Chapidze Heart Center, Tbilisi, Georgia.
Background: The use of beta-blockers in treating resistant hypertension remains poorly understood. While PATHWAY-2 showed a systolic blood pressure benefit with bisoprolol, further research is needed to evaluate other beta-blockers in terms of the effect of systolic blood pressure, assess diastolic blood pressure effects, and guide management in patients intolerant to CCBs as well.
Objectives: Our study aimed to evaluate the efficacy of Carvedilol (non-selective beta-blocker with alpha-1 blocking function) in the management of resistant hypertension, including in patients intolerant to calcium channel blockers.
Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses.
CNS Neurosci Ther
December 2024
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Background: Mild traumatic brain injury (mTBI) frequently results in persistent cognitive, emotional, and functional impairments, closely linked to disruptions in the default mode network (DMN). Understanding the mechanisms driving these network abnormalities is critical for advancing diagnostic and therapeutic strategies.
Methods: This study adopted a multimodal approach, combining functional connectivity (FC) analysis, diffusion tensor imaging (DTI), and gene expression profiling to investigate DMN disruptions in mTBI.
Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid-Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial.
Drug Des Devel Ther
December 2024
Department of Anaesthesiology, Peking University People's Hospital, Peking, People's Republic of China.
Background: The 15° left tilt position during caesarean delivery has been recommended by guidelines for many years, but recent studies have questioned the clinical benefit of left tilt position. We hypothesize that using a higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH, compared to the 15° left tilt position.
Methods: Healthy women undergoing elective caesarean delivery were randomized to the supine position (n = 62) or 15° left tilt position (n = 62) after spinal anaesthesia (0.
Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.
Interv Pain Med
December 2024
Department of Physical and Rehabilitation Medicine, University of Turku, Turku, Finland.
Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.
Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.
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