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| http://dx.doi.org/10.1016/j.lana.2023.100664 | DOI Listing |
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RET signalling in the pituitary: a double-edged sword for differentiation, apoptosis and therapeutic strategies in acromegaly.
Endocr Relat Cancer
January 2025
C Alvarez, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
The discovery of RET mutations in Multiple Endocrine Neoplasia 2A (MEN2A) in 1993 ignited a revolution in our understanding of this versatile receptor. Since then, RET's influence has expanded to encompass diverse organs, including the pituitary gland. This review explores the multifaceted role of RET in somatotrophs, focusing on two opposing pathways: proliferation versus differentiation and apoptosis.
View Article and Find Full Text PDFRetrospective Audit of Transfusion Reactions in a Tertiary-Care Hospital in South India.
Cureus
December 2024
Pathology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, IND.
Background: Blood transfusion is a double-edged sword, as it is a life-saving intervention but is also associated with various adverse reactions. However, blood transfusion safety can be improved by identifying these adverse reactions and taking appropriate interventions. Therefore, in this study, we aimed to determine the frequency and type of transfusion reactions occurring among in-patients at our hospital, as reported to our institute's blood center.
View Article and Find Full Text PDFChallenge-Hindrance Stressors and Novice Nurses' Safety Behaviour: The Mediating Role of Regulatory Focus and the Moderating Role of Workplace Spirituality.
J Adv Nurs
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School of Nursing and Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Aims: This study aims to investigate the impact of challenge-hindrance stressors on novice nurses' safety behaviour, the mediating effect of regulatory focus, and the moderating effect of workplace spirituality.
Background: The relationship between challenge-hindrance stressors and novice nurses' safety behaviour has rarely been investigated, despite the global concern for patient safety in healthcare systems. Previous research suggests that regulatory focus and workplace spirituality matter for nurse safety behaviour, but the relationship between them remains unclear.
Transfusion History Is More Predictive Than Serum Ferritin Level in Prediction of Hypothyroidism in Transfusion Dependent Thalassemia.
Mymensingh Med J
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Dr Khaza Amirul Islam, Medical Officer (Haematology), Shaheed Ziaur Rahman Medical College Hospital, Bogra, Bangladesh; E-mail:
Transfusion dependent thalassemia (TDT) patients require a regular blood transfusion to survive. Without adequate transfusion support, they suffer many complications, and have a short life span. Near about 200 milligrams of iron remains within a single Red cell concentrate (RCC) unit.
View Article and Find Full Text PDFAcetylation of E2F1 at K125 facilitates cell apoptosis under serum stress.
Transl Oncol
December 2024
Department of General Surgery, Sanmen People's Hospital, Sanmen 317100, China. Electronic address:
Article Synopsis
- E2F1 is a vital transcription factor involved in regulating the cell cycle and is often found at high levels in cancer cells.
- Recent research indicates that E2F1 can also trigger apoptosis (cell death) under stress conditions, posing a dual role in cell survival and death.
- This study reveals that acetylation of E2F1 at K125 during serum stress enhances its ability to promote the expression of Fas and BAX, leading to the activation of caspase-3 and apoptosis in liver cancer cells.
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