Charles I of Spain and V of Germany was one of the most prominent figures in Christendom. The vast empire ruled by the monarch extended across multiple continents. However, the final years of his life were overshadowed by depression and incapacitating joint degeneration, leading him to retire to the Monastery of Yuste in Cáceres, Spain. It was there that he contracted malaria, a disease that ultimately claimed his life. In this article, we evaluate the studies conducted on one of his mummified fingers to confirm the presence of malaria and investigate the cause of his joint degeneration, which was attributed to intense deposits of uric acid.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810993 | PMC |
| http://dx.doi.org/10.3389/fmed.2023.1287041 | DOI Listing |
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Frequency of and reasons for medication non-fulfillment and non-persistence among American adults with chronic disease in 2008.
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September 2011
US Outcomes Research, Merck & Co., Inc., North Wales, PA, USA.
OBJECTIVE To identify self-reported reasons why adults with chronic disease do not fill a new prescription (medication non-fulfillment) and/or stop taking a medication without their physician telling them to do so (lack of medication persistence). METHODS Participants were sampled in 2008 from a national, internet-based panel of American adults with chronic disease. A total of 19 830 respondents answered questions about medication non-fulfillment and medication non-persistence and reasons for non-fulfillment and non-persistence.
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