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Neoadjuvant therapy for resectable melanoma. | LitMetric

Neoadjuvant therapy for resectable melanoma.

Clin Exp Metastasis

Department of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Maloney 4 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Published: August 2024

AI Article Synopsis

Article Abstract

The standard of care for patients with resectable stage III/IV melanoma classically included upfront resection with adjuvant therapy. However, in more recent years, the amount of systemic therapies available for neoadjuvant use for these patients has increased. This article reviewed clinical trials investigating neoadjuvant therapy for patients with resectable stage III/IV melanoma. The outcomes of these trials have identified optimal treatment regimens to maximise patient response and minimize toxicities. Additionally, the date demonstrate advantages to neoadjuvant treatment compared to adjuvant therapy alone. Further research is needed to utilize a patient's response to neoadjuvant treatment for prognostication and creation of an individualized treatment plan.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283575PMC
http://dx.doi.org/10.1007/s10585-023-10263-1DOI Listing

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