AI Article Synopsis
- The study aimed to evaluate how well PET/CT scans can determine lymph node (LN) status in rectal cancer by analyzing existing diagnostic research.
- A total of 15 studies involving 1209 patients showed that while PET/CT had high specificity (94%) for detecting LN metastasis, its sensitivity was only moderate (62%).
- The findings suggest that while PET/CT is useful for ruling out LN metastasis, its moderate sensitivity indicates limitations in accurately identifying positive cases.
Article Abstract
Purpose: To obtain performance values of PET/CT for determining the nodal status of rectal cancer.
Materials: A comprehensive literature search was performed on PubMed and Embase for original diagnostic accuracy studies on the diagnostic performance of PET-CT for detection of LN metastasis in rectal cancer. The QUADAS-2 was used to evaluate the methodological quality of each study. Pooled sensitivity, specificity, and AUC were calculated to estimate the diagnostic role of PET/CT using a random-effects model. A subgroup analysis was performed to investigate the influence of different parameters on diagnostic performance.
Results: A total of 15 studies and 1209 patients were included. A publication bias was observed. The pooled sensitivity, specificity, and AUC for PET/CT was 0.62 (95% CI 0.49, 0.74), 0.94 (95% CI 0.87, 0.97), and 0.87 (95% CI 0.83-0.89), respectively. Per-node basis yields higher accuracy than per-patient basis, with pooled sensitivities of 0.65 (95% CI 0.50-0.79) vs. 0.56 (95% CI 0.36-0.77) and specificities of 0.96 (95% CI 0.92-1.00) vs. 0.88 (95% CI 0.76-1.00), but there were no significant differences in diagnostic accuracy.
Conclusion: PET/CT has high specificity but moderate sensitivity for the detection of LN metastasis in rectal cancer. The current data suggests that the diagnostic capabilities of this method is limited due to its moderate sensitivity.
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| http://dx.doi.org/10.1007/s00261-023-04140-4 | DOI Listing |
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