AI Article Synopsis
- Oligomeric clusters of amyloid-β (Aβ) are key indicators of Alzheimer's disease, but current detection methods for these clusters in brain tissue are inadequate.
- Researchers have developed synthetic M13 bacteriophages that display Aβ-derived peptides and can specifically interact with Aβ-oligomers, allowing them to identify these aggregates in brain tissue from APP/PS1-transgenic mice before the formation of Aβ-plaques.
- The bacteriophages also successfully detected small Aβ-aggregates in post-mortem hippocampal tissue from Alzheimer's patients, suggesting they could be an effective and cost-efficient tool for identifying Aβ-oligomers in
Article Abstract
Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer's disease (AD). However, proficient methods to detect Aβ-oligomers in brain tissue are lacking. Here we show that synthetic M13 bacteriophages displaying Aβ-derived peptides on their surface preferentially interact with Aβ-oligomers. When exposed to brain tissue isolated from APP/PS1-transgenic mice, these bacteriophages detect small-sized Aβ-aggregates in hippocampus at an early age, prior to the occurrence of Aβ-plaques. Similarly, the bacteriophages reveal the presence of such small Aβ-aggregates in post-mortem hippocampus tissue of AD-patients. These results advocate bacteriophages displaying Aβ-peptides as a convenient and low-cost tool to identify Aβ-oligomers in post-mortem brain tissue of AD-model mice and AD-patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821927 | PMC |
| http://dx.doi.org/10.1038/s42003-024-05806-5 | DOI Listing |
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