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Towards elimination of Neglected Tropical Diseases: Strengthening partnerships, fostering collaboration, and promoting country ownership.
Int J Infect Dis
January 2025
College of Medical Sciences, Njala University, Bo Campus, Sierra Leone; International Society for Infectious Diseases; Biological Sciences Department, Fourah Bay College, University of Sierra Leone. Electronic address:
Systems Thinking in the Prevention, Control, and Elimination of Neglected Tropical Diseases 2 (NTDs).
Int J Infect Dis
January 2025
The END Fund, 2 Park Avenue 28th Floor, New York, NY, USA.
It is estimated that more than one billion people are affected by Neglected Tropical Diseases (NTDs). Whilst there are existing treatments to reduce morbidity, a major challenge is creating robust programs that are both country led and leverage the existing health systems. Using a systems thinking approach is a critical component for integrating NTD services, as it takes into account all aspects of what might otherwise be considered fragmented systems to create a more efficient system.
View Article and Find Full Text PDFMolecular xenomonitoring of Wuchereria bancrofti infection in three different evaluation settings of lymphatic filariasis elimination programme in India.
Int J Infect Dis
January 2025
ICMR-Vector Control Research Centre, Puducherry, India.
Background: Molecular xenomonitoring (MX) is one of the recommended post-validation surveillance tools to detect early signals of lymphatic filariasis (LF) infection. This study reports the MX results of Culex quinquefasciatus transmitted Wuchereria bancrofti in three evaluation units of different settings in India.
Methods: Female Cx.
Sensitivity of anti-filarial antibodies for lymphatic filariasis surveillance: Insights from a serological survey in Samoa in 2018.
PLoS Negl Trop Dis
January 2025
UQ Centre for Clinical Research, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Background: Sensitive diagnostic tools that signal lymphatic filariasis (LF) transmission are needed to monitor the progress of LF elimination programs. Anti-filarial antibody (Ab) markers could be more sensitive than antigen (Ag) point-of-care tests for monitoring LF transmission in some settings. This study aimed to investigate the sensitivity of anti-filarial Abs for detecting signals of LF transmission in Samoa by i) investigating the sensitivity and specificity of Ab to identify Ag-positives; ii) estimating the average number needed to test (NNTestav) to identify LF-seropositives (seropositive for Ag and/or any Ab), and iii) compare the efficiency of the different serological indicators by target age group and sampling design.
View Article and Find Full Text PDFShrinking the lymphatic filariasis map of Zimbabwe: Reassessing the population requiring treatment through confirmatory mapping.
Int J Infect Dis
January 2025
Kenya Medical Research Institute, Nairobi, Kenya.
Objectives: Zimbabwe is endemic for lymphatic filariasis (LF) with 39 districts identified for mass drug administration (MDA) in 2014. The objective of this study was to reassess the current population requiring MDA.
Methods: The LF confirmatory mapping method was used to evaluate the prevalence of circulating filarial antigens (CFA) among school-aged children (9-14 years) in previously endemic districts.
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