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Calcium homeostasis modulator 2 (Calhm2) as slowly activating membrane current channel in mouse B cells. | LitMetric

Calcium homeostasis modulator 2 (Calhm2) as slowly activating membrane current channel in mouse B cells.

Biochem Biophys Res Commun

Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea; Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea. Electronic address:

Published: March 2024

AI Article Synopsis

Article Abstract

In mouse B lymphocytes, an unidentified slow-activating voltage-dependent current resembling the characteristics of the Calhm family ion channel (I) was investigated. RT-PCR analysis revealed the presence of Calhm2 and 6 transcripts, with subsequent whole-cell patch-clamp studies indicating that the I is augmented by heat, alkaline pH, and low extracellular [Ca]. Overexpression of Calhm2, but not Calhm6, in N2A cells recapitulated I. Moreover, Calhm2 knockdown in Bal-17 cells abolished I. We firstly identify the voltage-dependent ion channel function of the Calhm2 in the mouse immune cells. ATP release assays in primary mouse B cells suggested a significant contribution of Calhm2 for purinergic signaling at physiological temperature.

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http://dx.doi.org/10.1016/j.bbrc.2024.149561DOI Listing

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