In this paper, the results obtained in the development of ceramic resin feedstock for stereolithography are shown. Hydroxyapatite and silica are used as source of ceramic. Hydroxyapatite is extracted from bovine bone, which enhances bioactivity of ceramic scaffold. The influence of hydroxyapatite amount in polymer-based slurry on the viscosity and printability of feedstock is explored. Hydroxyapatite and silica containing scaffolds are successfully obtained by stereolithography. Influence of hydroxyapatite/silica ratio on the bioactivity, biodegradability and mechanical properties of the scaffolds is also studied. It was observed that higher concentrations of hydroxyapatite led to improved mechanical strength of the scuffolds but increased viscosity of the slurry, affecting printability. Cell viability assays and cell visualization experiments indicated that the scaffolds not cause significant cell toxicity.
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Article Synopsis
- This study explored how adding hydroxyapatite and silica aerogel nanoparticles affects the properties of epoxy resin, particularly focusing on density, tensile strength, and impact resistance.
- It utilized Response Surface Methodology (RSM) and Box-Behnken Design (BBD) to analyze the combined effects of the two materials, revealing optimal compositions for improved mechanical performance.
- Results showed that the optimal addition of hydroxyapatite (2.38 wt%) and silica aerogels (4 wt%) maximized tensile strength and impact resistance, while also reducing the density of the epoxy composites.
Mechanical, Structural, and Biological Properties of Chitosan/Hydroxyapatite/Silica Composites for Bone Tissue Engineering.
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Faculty of Process and Environmental Engineering, Lodz University of Technology, 90-924 Lodz, Poland.
The aim of this work was to fabricate novel bioactive composites based on chitosan and non-organic silica, reinforced with calcium β-glycerophosphate (Ca-GP), sodium β-glycerophosphate pentahydrate (Na-GP), and hydroxyapatite powder (HAp) in a range of concentrations using the sol-gel method. The effect of HAp, Na-GP, and Ca-GP contents on the mechanical properties, i.e.
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