AI Article Synopsis
- - The Golgi complex is a crucial organelle responsible for processing and sorting proteins and lipids, showing a dynamic structure that changes during various cellular processes like division and migration.
- - It can fragment or disperse in response to both normal physiological conditions and pathological issues, including diseases like neurodegenerative disorders and cancer.
- - The review summarizes current understanding of the Golgi's structure and changes, along with methods used to study its organization in both healthy and diseased states.
Article Abstract
The Golgi complex is a highly dynamic and tightly regulated cellular organelle with essential roles in the processing as well as the sorting of proteins and lipids. Its structure undergoes rapid disassembly and reassembly during normal physiological processes, including cell division, migration, polarization, differentiation, and cell death. Golgi dispersal or fragmentation also occurs in pathological conditions, such as neurodegenerative diseases, infectious diseases, congenital disorders of glycosylation diseases, and cancer. In this review, current knowledge about both structural organization and morphological alterations in the Golgi in physiological and pathological conditions is summarized together with the methodologies that help to reveal its structure.
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| http://dx.doi.org/10.1007/s11033-023-09153-2 | DOI Listing |
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