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A Review on Synthetic Thiazole Derivatives as an Antimalarial Agent. | LitMetric
Background : Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmacologically active compounds demonstrates the adaptability of these derivatives.Methods : The current study attempted to review and compile the contributions of numerous researchers over the last 20 years to the medicinal importance of these scaffolds, with a primary focus on antimalarial activity. The review is based on an extensive search of PubMed, Google Scholar, Elsevier, and other renowned journal sites for a thorough literature survey involving various research and review articles.Results : A comprehensive review of the antimalarial activity of the thiazole scaffold revealed potential therapeutic targets in species. Furthermore, the correlation of structure-activity-relationship (SAR) studies from various articles suggests that the thiazole ring has therapeutic potential.Conclusion : This article intends to point researchers in the right direction for developing potential thiazole-based compounds as antimalarial agents in the future.
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