Background: Some patients with neovascular age-related macular degeneration (nAMD) respond insufficiently to anti-VEGF treatment despite maximal monthly intravitreal injections. Their short-term response between injections was investigated for extent and visual prognosis.
Subjects/methods: Monocentric retrospective observational study. 45 eyes from 41 patients with refractory nAMD (who previously received at least 12 months of anti-VEGF treatment), evaluated by optical coherence tomography (OCT) in between monthly anti-VEGF injections. The fluid profile on OCT was evaluated before, 1 week after, and 1 month after an intravitreal injection, using central retinal thickness (CRT), manual measurements, and fluid specific volumetric measurements performed by an automated algorithm based on artificial intelligence.
Results: A significant improvement was found at week 1 in terms of CRT (p < 0.0001), intraretinal (IRF) (p = 0.007), subretinal fluid (SRF) (p < 0.0001), and pigment epithelium detachment (PED) volume (p < 0.0001). Volumetric fluid measures revealed a >50% reduction at week 1 for both IRF and SRF for approximately two-thirds of eyes. Poorer short-term response was associated with larger exudative fluid amounts (IRF + SRF) (p = 0.003), larger PED (p = 0.007), lower visual acuity (p = 0.004) and less anatomic changes at treatment initiation (p < 0.0001). Univariate and multivariate analysis revealed that visual outcomes 4 and 5 years later was significantly worse with weaker short-term responsiveness (p = 0.005), with the presence of atrophy (p = 0.01) and larger PED volumes (p = 0.002).
Conclusions: Incomplete responders to anti-VEGF showed a significant short-term response, identifiable at 1 week after injection, with rapid recurrence at 1 month. Weaker short-term responsiveness at 1 week was associated with poorer long term visual prognosis. These patients may need adjuvant treatment to improve their prognosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076480 | PMC |
| http://dx.doi.org/10.1038/s41433-023-02900-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep brain stimulation of the medial forebrain bundle promotes the extinction of active avoidance and is associated with mossy fibber sprouting in the hippocampus.
Behav Brain Res
December 2024
Departament de Biologia, Universitat de Girona, Girona, Spain. Electronic address:
Background: Post-traumatic stress disorder (PTSD) causes intrusive symptoms and avoidance behaviours due to dysregulation in various brain regions, including the hippocampus. Deep brain stimulation (DBS) shows promise for refractory PTSD cases. In rodents, DBS improves fear extinction and reduces anxiety-like behaviours, but its effects on active-avoidance extinction remain unexplored.
View Article and Find Full Text PDFCytoprotective Effects and Intranuclear Localization of Sulfur-Containing Derivative of Buckminsterfullerene.
Front Biosci (Landmark Ed)
December 2024
Research Centre for Medical Genetics, 115522 Moscow, Russia.
Background: There is a growing interest in exploring the biological characteristics of nanoparticles and exploring their potential applications. However, there is still a lack of research into the potential genotoxicity of fullerene derivatives and their impact on gene expression in human cells. In this study, we investigated the effects of a water-soluble fullerene derivative, C60[C6H4SCH2COOK]5H (F1), on human embryonic lung fibroblasts (HELF).
View Article and Find Full Text PDFA novel ensemble ARIMA-LSTM approach for evaluating COVID-19 cases and future outbreak preparedness.
Health Care Sci
December 2024
School of Computer Science and Engineering, Vellore Institute of Technology Vellore India.
Background: The global impact of the highly contagious COVID-19 virus has created unprecedented challenges, significantly impacting public health and economies worldwide. This research article conducts a time series analysis of COVID-19 data across various countries, including India, Brazil, Russia, and the United States, with a particular emphasis on total confirmed cases.
Methods: The proposed approach combines auto-regressive integrated moving average (ARIMA)'s ability to capture linear trends and seasonality with long short-term memory (LSTM) networks, which are designed to learn complex nonlinear dependencies in the data.
Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants.
Part Fibre Toxicol
December 2024
Division of Cardiology, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, CHS 43-264, P.O. Box 951679, Los Angeles, CA, 90095, USA.
Background: Exposure to air pollution is associated with worldwide morbidity and mortality. Diesel exhaust (DE) emissions are important contributors which induce vascular inflammation and metabolic disturbances by unknown mechanisms. We aimed to determine molecular pathways activated by DE in the liver that could be responsible for its cardiometabolic toxicity.
View Article and Find Full Text PDFA forecasting tool for optimized emission control strategies to achieve short-term air quality attainment.
J Environ Manage
December 2024
State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing, 100084, China.
Optimizing an emergency air pollution control strategy for haze events presents a significant challenge due to the extensive computational demands required to quantify the complex nonlinearity associated with controls on diverse air pollutants and regional sources. In this study, we developed a forecasting tool for emergency air pollution control strategies based on a predictive response surface model that quantifies PM responses to emission changes from different pollutants and regions. This tool is equipped to assess the effectiveness of emergency control measures corresponding to various air pollution alerts and to formulate an optimized control strategy aimed at specific PM targets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!