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The association of congenital diaphragmatic hernia with scoliosis.
Spine Deform
January 2025
Great North Children's Hospital, Newcastle Upon Tyne, UK.
Purpose: To determine the prevalence of scoliosis in patients who have undergone surgical repair of CDH and attempt to assess the aetiology of scoliosis in affected cases.
Methods: A prospectively collected database of patients with CDH treated in a single centre between 1997 and 2023 was reviewed. Cases with adequate records who continued to reside locally having survived beyond age 2 and > 2 years following CDH repair were included.
Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases.
Cell Biol Toxicol
November 2024
Medical Clinic III for Pneumology, Allergology and Sleep Medicine, Bergmannsheil University Hospital, Ruhr-University Bochum, Bürkle-de-La-Camp-Platz 1, 44789, Bochum, Germany.
Background: Hypersensitivity to odorants like perfumes can induce or promote asthma with non-type 2 inflammation for which therapeutic options are limited. Cell death of primary bronchial epithelial cells (PBECs) and the release of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-8 are key in the pathogenesis. Extra-nasal olfactory receptors (ORs) can influence cellular processes involved in asthma.
View Article and Find Full Text PDFAn integrated approach to evaluating water contaminants and evaporation in agricultural water distribution systems.
Ecotoxicol Environ Saf
November 2024
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA. Electronic address:
This study presents an innovative approach for assessing water quality in agricultural irrigation networks, integrating stable isotope analysis, in vivo zebrafish screening, and comprehensive chemical profiling to investigate the occurrence, transformation, and potential toxicity of organic contaminants. Stable isotope analysis was used to measure evaporation as a proxy for water residence time in the canal, while liquid chromatography-high resolution mass spectrometry (LC-HRMS) identified a range of organic compounds in water samples collected from both the irrigation canal and its source river. Results indicated a reduction in contaminant levels in the canal compared to the river, with the most significant evaporation and concentration changes occurring at a holding reservoir, suggesting that managing residence time could help reduce water loss in arid irrigation networks.
View Article and Find Full Text PDFIs MAGEC X better than earlier designs of magnetically controlled growing rod: an explant study.
Eur Spine J
January 2025
Great North Children's Hospital, Newcastle Upon Tyne, UK.
Purpose: Determine the performance of MAGEC X rods through retrieval analysis and comparison with clinical data.
Methods: A multicentre explant database was searched to identify cases using MAGEC X device. Clinical and surgical data was gathered prospectively.
A rapid assessment methodology for quantifying and visualizing functional landscape connectivity.
Front Conserv Sci
July 2024
Pacific Ecological Systems Division, US Environmental Protection Agency, Corvallis, OR, United States.
Context: The number of publications that evaluate or use landscape connectivity has grown dramatically in recent years. But the biological realism of common connectivity assessments remains limited. To address this shortcoming, I introduce a flexible methodology for evaluating functional landscape connectivity that can be quick to implement, biologically nuanced, and straightforward to interpret.
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