High Diagnostic Yield of Abnormal Endoscopic Findings in the Evaluation of Laryngopharyngeal Reflux.

Clin Gastroenterol Hepatol

Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

Published: August 2024

AI Article Synopsis

  • Esophagogastroduodenoscopy (EGD) is suggested for patients with typical GERD symptoms who do not respond to proton pump inhibitors, to assess for erosive disease and ensure there are no other conditions.
  • The utility of EGD is uncertain for diagnosing laryngopharyngeal reflux (LPR), with ambulatory reflux monitoring being the current standard for such evaluations.
  • This study aimed to examine endoscopic findings in patients with chronic laryngeal symptoms, compare results between those with and without esophageal reflux symptoms, and investigate the link between endoscopic results and GERD diagnosed through reflux monitoring.

Article Abstract

Esophagogastroduodenoscopy (EGD) is recommended in patients with typical gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation, chest pain) in the setting of proton pump inhibitor (PPI) nonresponse. EGD evaluates for erosive disease, assesses antireflux barrier integrity, excludes non-GERD conditions, and, in the absence of erosive findings, is followed by reflux testing. The diagnostic utility of EGD is less clear in the evaluation for laryngopharyngeal reflux (LPR), and the current reference standard is ambulatory reflux monitoring. This study of patients referred for evaluation of chronic laryngeal symptoms had the following aims: (1) to characterize endoscopic findings, (2) to discern whether findings differed between patients with or without concomitant esophageal reflux symptoms, and (3) to measure the association between endoscopic findings and objective GERD on ambulatory reflux monitoring.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266523PMC
http://dx.doi.org/10.1016/j.cgh.2024.01.012DOI Listing

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