AI Article Synopsis
- - The advancement of diagnostic technology has made true acute undifferentiated leukemia (AUL) increasingly rare, with the unusual occurrence of AUL associated with extramedullary sarcoma.
- - A specific case of AUL was documented where tumor cells from both the bone marrow and lymph nodes displayed similar origins and expressed mainly stem cell markers, without signs of myeloid or lymphoblastic markers.
- - Treatment with azacitidine combined with HIA (homoharringtonine, idarubicin, and Ara-C) resulted in complete remission for the patient, highlighting the effectiveness of using comprehensive immune marker detection for diagnosis and treatment.
Article Abstract
Background: With the advancement of diagnostic technology, true acute undifferentiated leukemia (AUL) is becoming more rare, and AUL with extramedullary sarcoma has not been reported.
Case Presentation: This article reports a case of AUL with extramedullary sarcoma. Flow cytometric analysis of the bone marrow and lymph nodes indicated that the tumor cells of both were of the same origin and mainly expressed stem cell markers and CD7, no myeloid-specific markers, T-lymphoblastic-related markers, and B-lymphoblastic-related markers. Although the priming regimen combined with azacitidine was ineffective, complete remission was achieved by switching to azacitidine combined with HIA (homoharringtonine, idarubicin plus Ara-C).
Conclusion: To diagnosis de novo acute leukemia with extensive and comprehensive cellular immune maker detection is available and credible, the expression of a single relatively nonspecific myeloid antigen as a immune maker to detect AUL or AUL associated with sarcoma is precise and effective in our case, which patient was benefit from HIA regiment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817018 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000036948 | DOI Listing |
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