AI Article Synopsis
- The article discusses the development of newly designed peptides with potential biological activity.
- The researchers created nine peptides made of six amino acids, focusing on enhancing their hydrophobicity by adding palmitic or lithocholic acid to the amino end.
- The study found that these modified lipopeptides exhibited strong antimicrobial effects, particularly against certain bacteria and fungi, and one specific peptide demonstrated high efficacy against human liver cancer cells.
Article Abstract
The aim of this article is to introduce the topic of newly designed peptides as well as their biological activity. We designed nine encoded peptides composed of six amino acids. All these peptides were synthesized with C-terminal amidation. To investigate the importance of increased hydrophobicity at the amino end of the peptides, all of them were subsequently synthesized with palmitic or lithocholic acid at the N-terminus. Antimicrobial activity was tested on Gram-positive and Gram-negative bacteria and fungi. Cytotoxicity was measured on HepG2 and HEK 293 T cell cultures. Peptides bearing a hydrophobic group exhibited the best antimicrobial activity. Lipopeptides with palmitic or lithocholic acid (PAL or LCA peptides) at the N-terminus and with C-terminal amidation were highly active against Gram-positive bacteria, especially against strains of Staphylococcus aureus and Candida tropicalis. The LCA peptide SHP 1.3 with the sequence LCA-LVKRAG-NH, had high efficiency on HepG2 human liver hepatocellular carcinoma cells (97%).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11003925 | PMC |
| http://dx.doi.org/10.1007/s12223-024-01132-9 | DOI Listing |
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