Anti-Idiotypic mRNA Vaccine to Treat Autoimmune Disorders.

Vaccines (Basel)

College of Pharmacy, University of Illinois, Chicago, IL 60012, USA.

Published: December 2023

The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or treatment options, except for temporary symptomatic management, leading to enormous human suffering and a monumental financial burden. The autoantibodies formed in most ADs have been identified, allowing the development of novel anti-idiotypic antibodies to mute the autoantibodies using vaccines. Nucleoside vaccines have been successfully tested as antigen-specific immunotherapies (ASI), with mRNA technology offering multi-epitope targeting to mute multiple autoantibodies. This paper proposes using mRNA technology to produce anti-idiotypic antibodies with broad effectiveness in preventing and treating them. This paper delves into the state-of-the-art mRNA design strategies used to develop novel ASIs by selecting appropriate T cell and B cell epitopes to generate anti-idiotypic antibodies. The low cost and fast development of mRNA vaccines make this technology the most affordable for the global control of ADs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10819008PMC
http://dx.doi.org/10.3390/vaccines12010009DOI Listing

Publication Analysis

Top Keywords

anti-idiotypic antibodies
12
autoimmune disorders
8
mrna technology
8
anti-idiotypic
4
anti-idiotypic mrna
4
mrna vaccine
4
vaccine treat
4
treat autoimmune
4
disorders 80+
4
80+ existing
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!