Artificial intelligence (AI)- and deep learning (DL)-based systems have shown significant progress in the field of macular disorders, demonstrating high performance in detecting retinal fluid and assessing anatomical changes during disease progression. This study aimed to validate an AI algorithm for identifying and quantifying prognostic factors in visual recovery after macular hole (MH) surgery by analyzing major optical coherence tomography (OCT) biomarkers. This study included 20 patients who underwent vitrectomy for a full-thickness macular hole (FTMH). The mean diameter of the FTMH was measured at 285.36 ± 97.4 μm. The preoperative best-corrected visual acuity (BCVA) was 0.76 ± 0.06 logMAR, improving to 0.38 ± 0.16 postoperatively, with a statistically significant difference ( = 0.001). AI software was utilized to assess biomarkers, such as intraretinal fluid (IRF) and subretinal fluid (SRF) volume, external limiting membrane (ELM) and ellipsoid zone (EZ) integrity, and retinal hyperreflective foci (HRF). The AI analysis showed a significant decrease in IRF volume, from 0.08 ± 0.12 mm preoperatively to 0.01 ± 0.01 mm postoperatively. ELM interruption improved from 79% ± 18% to 34% ± 37% after surgery ( = 0.006), whereas EZ interruption improved from 80% ± 22% to 40% ± 36% ( = 0.007) postoperatively. Additionally, the study revealed a negative correlation between preoperative IRF volume and postoperative BCVA recovery, suggesting that greater preoperative fluid volumes may hinder visual improvement. The integrity of the ELM and EZ was found to be essential for postoperative visual acuity improvement, with their disruption negatively impacting visual recovery. The study highlights the potential of AI in quantifying OCT biomarkers for managing MHs and improving patient care.
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http://dx.doi.org/10.3390/jcm13020628 | DOI Listing |
Int Med Case Rep J
December 2024
Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia.
Purpose: To report a case of partial detachment of an inverted internal limiting membrane (ILM) flap following a successful closure of a full-thickness traumatic macular hole.
Observations: A 24-year-old male patient presented with a history of a blunt trauma and a full-thickness macular hole. Visual acuity was (20/50) then deteriorated to (20/100) prior to surgery.
J Clin Med
November 2024
Department of Ophthalmology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
The purpose of this study was to evaluate the anatomical and visual outcomes of patients with stage IV full-thickness macular holes (FTMHs) treated by the cabbage leaf inverted internal limiting membrane (ILM) flap technique. We conducted a retrospective study, enrolling patients with stage IV FTMH operated by a single surgeon. Six patients with FTMH and no other known ocular comorbidities were included in the study.
View Article and Find Full Text PDFInt Ophthalmol
December 2024
Eye Clinic, University of Health Sciences Umraniye Training and Research Hospital, 34766, Umraniye, Istanbul, Turkey.
Background: To execute comprehensive study about optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) findings in fibromyalgia (FM) to elaborate macula, optic disk changes.
Methods: A total of 84 participants comprising 44 FM patients and 40 healthy controls were included. Macular full thickness, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL)+, GCL++, superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ), circumpapillary vessel density (cpVD), RNFL measurements were evaluated using OCT/OCTA.
J Fr Ophtalmol
December 2024
Department of Ophthalmology, Kasr El Aini Hospital, Cairo University, El-Manial, Cairo, Egypt.
Purpose: To evaluate the outcomes of pars plana vitrectomy (PPV) for full thickness macular holes (FTMH) in ocular Behçet's disease.
Methods: Eyes with FTMH as confirmed on optical coherence tomography in patients with active ocular Behçet's disease (AOBD) were included in this study. These eyes underwent PPV, epiretinal membrane (ERM) removal, internal limiting membrane (ILM) peel, and a tamponade injection.
Retina
December 2024
Department of Ophthalmology, Akita University, 44-2 Hasunuma, Akita, Akita Prefecture, Japan.
Purpose: This study investigated the clinical features and surgical outcomes of full-thickness macular holes (FTMHs) without focal vitreomacular traction (VMT) and discusses possible underlying mechanisms.
Methods: This was a retrospective observational study included patients aged 18 years or older with stage 2 FTMHs who underwent pars plana vitrectomy at three hospitals between December 2016 and March 2024. Patients diagnosed without focal VMT in the macula were classified as VMT- and those with focal VMT were classified as VMT+.
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