AI Article Synopsis
- - Primary squamous cell carcinoma of the thyroid is a rare and aggressive cancer with a poor survival rate, as highlighted by a case study of a 66-year-old man.
- - This patient experienced hypercalcemia (high calcium levels) and leukocytosis (high white blood cell count), which are believed to be symptoms of paraneoplastic syndrome—an effect caused by cancer not directly related to tumor spread.
- - The origins of this type of thyroid cancer are still debated among researchers, and the study discusses potential mechanisms behind the associated hypercalcemia and leukocytosis based on recent findings.
Article Abstract
Primary squamous cell carcinoma of the thyroid is an extremely rare, aggressive neoplasm with a uniformly poor prognosis. Described herein is a case of a 66-year-old man with primary squamous cell carcinoma of the thyroid associated with hypercalcemia (13 mg/dL [3.24 mmol/L]) and unexplained leukocytosis (28,400/mm3 [28.4 X 10(9)/L]). The histogenesis of squamous cell carcinoma of the thyroid remains controversial. The associated hypercalcemia and leukocytosis most likely represent a form of paraneoplastic syndrome; possible mechanisms will be discussed in the light of recent studies on tumor-derived mediators.
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