Background: Amyloid beta (Aβ) plaque density was examined in the amygdala of rhesus macaques, to elucidate the influence of age, diet and hormonal environment.

Methods: Luminex technology was used to measure cerebrospinal fluid (CSF) concentrations of Aβ and Aβ across three decades, while immunohistochemistry was used to examine Aβ plaque density in the amygdala.

Results: Aβ was found to be the predominant isoform of Aβ in the CSF, but neither Aβ or Aβ concentrations showed an age-related change, and the ratio of Aβ to Aβ showed only a marginal increase. Significantly fewer Aβ plaques were detected in the amygdala of old ovariectomized animals if they received estradiol HRT ( < 0.001); similar results were obtained regardless of whether they had been maintained on a regular monkey chow for ∼48 months or on a high-fat, high-sugar, Western-style diet for ∼30 months.

Conclusion: The results demonstrate that HRT involving estrogen can reduce Aβ plaque load in a cognitive brain region of aged non-human primates. The results from this translational animal model may therefore have clinical relevance to the treatment of AD in post-menopausal women, whether used alone, or as a supplement to current pharmacological and monoclonal antibody-based interventions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808750PMC
http://dx.doi.org/10.3389/fnagi.2023.1326747DOI Listing

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