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| http://dx.doi.org/10.1136/bcr-2023-256644 | DOI Listing |
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Warm Autoimmune Hemolytic Anemia as a Rare Presentation of Pre-fibrotic Primary Myelofibrosis.
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Hematology and Oncology, Olive View University of California Los Angeles (UCLA) Medical Center, Sylmar, USA.
Primary myelofibrosis (PMF) is an uncommon chronic myeloproliferative disorder that is commonly associated with Janus kinase 2 (JAK-2), calreticulin (CALR), or thrombopoietin receptor (MPL) mutations. Pre-fibrotic PMF (also known as pre-PMF or early PMF) is a subtype of PMF that is defined by a lower grade of fibrosis. In this report, we present a rare case of warm autoimmune hemolytic anemia (wAIHA) associated with pre-PMF.
View Article and Find Full Text PDFA Case of Autoimmune Myelofibrosis Associated With Autoimmune Hepatitis.
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August 2024
Saskatoon Cancer Center, Saskatchewan Cancer Agency, and College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Autoimmune myelofibrosis (AIMF) is a distinct, underrecognized, and rare cause of bone marrow fibrosis. It carries a favorable outcome and responds well to immunosuppression. Systemic lupus erythematosus is the most common association with AIMF, but there are other cases of associated autoimmune disorders defined in the literature.
View Article and Find Full Text PDFDelayed diagnosis of TAFRO syndrome: A case report.
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Department of Hematology, Peking University First Hospital, Beijing, China.
Article Synopsis
- TAFRO syndrome is a systemic inflammatory disorder characterized by symptoms like thrombocytopenia, fever, and organomegaly, resembling either a connective tissue or autoimmune disease, and is linked to idiopathic multicentric Castleman disease (iMCD).
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Autoimmune Myelofibrosis Revealing a Systemic Lupus Erythematosus.
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Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco.
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Small molecule drug discovery targeting the JAK-STAT pathway.
Pharmacol Res
June 2024
School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue homeostasis. Dysregulation of this pathway has been implicated in various diseases, including immunodeficiency, autoimmune conditions, hematological disorders, and certain cancers. Proteins within this pathway have emerged as effective therapeutic targets for managing these conditions, with various approaches developed to modulate key nodes in the signaling process, spanning from receptor engagement to transcription factor activation.
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