AI Article Synopsis
- A study investigated the impact of prenatal exposure to various non-organophosphate pesticides on the neurodevelopment of children at one year old, using urine samples from pregnant women to measure pesticide levels.
- Findings revealed that higher levels of 2,4-D were linked to lower language and motor skills in all children, while chlorpyrifos exposure correlated with reduced cognitive skills, particularly among boys.
- Additionally, girls showed lower language abilities with increased pyrimethanil exposure, but pyrethroid levels did not significantly affect developmental outcomes.
Article Abstract
Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides.
Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants' Environmental Health (ISA) birth cohort.
Methods: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1-3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations between exposures and neurodevelopmental outcomes (composite and z-scores) using single-chemical linear regression models adjusted for possible confounders (maternal education, parity, sex, gestational age at birth, child age, HOME-score, location of assessment, biomarkers of mancozeb), and studied effect-modification by sex. We evaluated non-linear associations of multiple pesticide exposures with Bayesian kernel machine regression (BKMR).
Results: We found higher prenatal urinary 2,4-D concentrations were associated with lower language (β = -2.0, 95 % confidence interval (CI) = -3.5, -0.5) and motor (β = -2.2, 95 %CI = -4.2, -0.1) composite scores among all children. Also, higher chlorpyrifos exposure [measured as urinary 3,5,6-trichloro-2-pyridinol (TCPy)] was associated with lower cognitive composite scores (β = -1.9, 95 %CI = -4.7, 0.8), and lower motor composite scores among boys (β = -3.8, 95 % CI = -7.7, 0.1) but not girls (β = 2.3, 95 %CI = -1.6, 6.3, pINT = 0.11). Finally, higher pyrimethanil was associated with lower language abilities among girls, but not boys. Pyrethroid metabolite concentrations did not explain variability in BSID-III composite scores. Associations were similar for BSID-III z-scores, and we found no evidence for non-linear associations or mixture effects.
Discussion: Prenatal exposure to common-use pesticides may affect children's neurodevelopment at 1-year of age, some effects may be sex-specific.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065598 | PMC |
| http://dx.doi.org/10.1016/j.envres.2024.118222 | DOI Listing |
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