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Clinical presentations and complications of lichen sclerosus: A systematic review.
J Dtsch Dermatol Ges
December 2024
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
Lichen sclerosus (LS) is a chronic, inflammatory dermatosis most commonly characterized by changes in skin pigmentation and pruritus, with associated dyspareunia and genital architectural changes. There are a variety of complications associated with LS, which further worsen a patient's health-related quality of life. A systematic review was conducted to summarize the literature regarding clinical features of LS, as well as LS-associated complications.
View Article and Find Full Text PDFHereditary Spiny Keratoderma in a Pediatric Patient: A Case Report and Literature Review.
Cureus
November 2024
Dermatology, Institute for Social Security and Services for State Workers Regional Hospital "Lic. Adolfo Lopez Mateos", Mexico City, MEX.
A 14-year-old male with disseminated superficial porokeratosis and a family history of the same lesions on his maternal side presented with spiny keratoderma. Spiny keratoderma is a dermatosis characterized by multiple punctate keratotic neoformations on the palms and soles. It is considered a rare disease, with fewer than 84 cases reported in the world medical literature to date.
View Article and Find Full Text PDFBone quality relies on hyaluronan synthesis - Insights from mice with complete knockout of hyaluronan synthase expression.
Matrix Biol Plus
December 2024
Dept. of Dermatology, Venereology and Allergology, Medical Faculty, Leipzig University, Germany.
Bone consists of a complex mineralised matrix that is maintained by a controlled equilibrium of synthesis and resorption by different cell types. Hyaluronan (HA) is an important glycosaminoglycan in many tissues including bone. Previously, the importance of HA synthesis for bone development during embryogenesis has been shown.
View Article and Find Full Text PDFFerroptosis: A novel cell death modality in or synergistic therapeutic strategy for photodynamic therapy.
Photodiagnosis Photodyn Ther
December 2024
Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. Electronic address:
Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent ideal strategies for tumor treatment. Photodynamic therapy (PDT) is a localized and relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis.
View Article and Find Full Text PDFPolygenic Score: A Tool for Evaluating the Genetic Background of Sporadic Hidradenitis Suppurativa.
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December 2024
Pediatric Department, Institute of Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy. Electronic address:
Sporadic Hidradenitis Suppurativa (spHS) is a multifactorial disease in which genetic predisposition is intertwined with environmental factors. Due to the still to date limited knowledge of spHS genetics, we calculated Polygenic scores (PGS) to study the genetic underpinnings that contribute to spHS within European demographic. 256 spHS patients and 1686 healthy controls were analyzed across 6 European clinical centers.
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