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[Clinical and genetic manifestations of left ventricular non-compaction in children]. | LitMetric

[Clinical and genetic manifestations of left ventricular non-compaction in children].

G Ital Cardiol (Rome)

Unità di Malattie Genetiche e Rare Cardiovascolari, Dipartimento di Scienze Mediche Traslazionali, Università della Campania "Luigi Vanvitelli, Ospedale Monaldi, Napoli - Institute of Cardiovascular Science, University College London, Londra, UK.

Published: February 2024

AI Article Synopsis

Article Abstract

Left ventricular non-compaction (LVNC) is a myocardial disease characterized by a two-layered structure typically seen at the apical and lateral left portions of the ventricular myocardium, distal to the papillary muscles. While considered a rare disease, its prevalence in children is increasing due to the increased awareness of this condition and improved resolution of imaging techniques. The etiology is heterogeneous, ranging from inherited conditions to acquired diseases. Although many patients are asymptomatic, some patients may experience adverse events, including heart failure, arrhythmias, or thromboembolic events. Several echocardiographic or cardiac magnetic resonance imaging diagnostic criteria have been proposed for diagnosing LVNC. However, their application in children is significantly limited. This review aims to describe the clinical and genetic characteristics of children with LVNC and discuss the role of the proposed diagnostic criteria.

Download full-text PDF

Source
http://dx.doi.org/10.1714/4187.41758DOI Listing

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