The epidemiology of blastomycosis in Vermont, USA, is poorly understood. Using insurance claims data, we estimated the mean annual blastomycosis incidence was 1.8 patients/100,000 persons during 2011-2020. Incidence and disease severity were highest in north-central counties. Our findings highlight a need for improved clinical awareness and expanded surveillance.
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http://dx.doi.org/10.3201/eid3002.230825 | DOI Listing |
Milbank Q
January 2025
Questrom School of Business, Boston University.
Unlabelled: Policy Points Cell and gene therapies (CGTs) offer treatment for rare and oftentimes deadly disease, but their prices are high, and payers may seek to limit spending. Total annual costs of covering all existing and expected CGTs for the entire US population 2023-2035 to amount to less than $20 per person and concentrate in commercial and state Medicaid plans. Reinsurance fees add to expected costs.
View Article and Find Full Text PDFWorld J Surg
January 2025
Precision Medicine Program, Hoag Family Cancer Institute, Newport Beach, California, USA.
Background: A recent prospective phase II study (ECOG-ACRIN E2211) demonstrated that MGMT deficiency was associated with a significant response to capecitabine and temozolomide (CAPTEM) in pancreatic neuroendocrine neoplasms (NENs); however, routine MGMT analysis in NENs was not recommended. Our study sought to demonstrate whether loss of MGMT protein expression is associated with improved overall survival (OS) in patients receiving CAPTEM for NENs from various tumor sites.
Materials And Methods: Paraffin-embedded tumor samples were evaluated by immunohistochemistry (IHC) using an MGMT monoclonal antibody.
Risk Anal
January 2025
School of Economics and Management, University of Chinese Academy of Sciences, Beijing, China.
The COVID-19 shows significant "catastrophe" characteristics. It has put tremendous pressure on various countries' government finances. A few studies have realized that insurance could be applied in the rescue of catastrophic epidemics to relieve government pressure and improve rescue efficiency.
View Article and Find Full Text PDFGeriatr Gerontol Int
January 2025
Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Aim: In the Japanese health checkup system for older adults aged ≥75 years, the Questionnaire for Medical Checkup of Old-Old (QMCOO) was adopted after 2020. However, the prognostic significance of this questionnaire for the incidence of functional disability is uncertain. The current study aimed to validate the prognostic significance of the QMCOO, and to develop a simple risk score for functional disability by analyzing health insurance claims data including annual health checkup data.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
February 2025
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Background: Frailty is an important prognostic indicator in older women with breast cancer. The Faurot frailty index, a validated claims-based frailty proxy measure, uses healthcare billing codes during a user-specified ascertainment window to predict frailty. We assessed how the duration of frailty ascertainment affected the ability of the Faurot frailty index to predict one-year mortality in women with stage I-II breast cancer.
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