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Chromatographic methods for the determination of toxicants in faeces.
J Chromatogr
September 1992
Department of Health Risk Analysis and Toxicology, University of Limburg, Maastricht, Netherlands.
Modern chromatographic techniques and their application in the determination of toxic compounds in faeces are reviewed. Faecal analysis may be of importance in toxicokinetic studies of xenobiotics in order to determine factors such as metabolism, body burden and major routes of elimination. Compounds of interest include various food constituents, drugs and occupational or environmental factors.
View Article and Find Full Text PDFQuantitative HPLC analysis of the level of fecapentaenes and their precursors in human feces by a chemical conversion method.
J Nat Prod
July 1990
Unilever Research Laboratories Vlaardingen, The Netherlands.
A fast and reliable hplc method for the quantitative analysis of total fecapentaene-12 (FP-12 and its precursors) and total fecapentaene-14 (FP-14 and its precursors) in human feces is described. The analysis is based on the rapid chemical conversion of fecapentaenes and their precursors to more stable methoxytetraenols and the use of synthetic, not naturally occurring, fecapentaene-13 (FP-13) as an internal standard. The synthesis and physical properties of this internal standard are described.
View Article and Find Full Text PDFThe precursors of fecapentaenes: purification and properties of a novel plasmalogen.
Lipids
May 1989
Department of Anaerobic Microbiology, State University, Blacksburg, VA 24061.
Fecapentaene-12 and fecapentaene-14 are genotoxic poly-unsaturated ether-lipids produced by the colonic microflora in humans and pigs. Although the fecapentaenes have been extensively characterized, little is known about the nature of the precursors from which they are produced. We purified one form of these precursors from feces of an individual who excreted high levels of fecapentaene-12 and its precursors.
View Article and Find Full Text PDFCase-control study of colorectal cancer and fecapentaene excretion.
Cancer Res
March 1989
Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892.
The fecapentaenes are potent mutagens found in high concentrations in the stools of some individuals. These compounds are produced in vivo by common species of the colonic microflora, from precursors of unknown origin. The fecapentaenes have been postulated to increase the risk of colorectal cancer.
View Article and Find Full Text PDFRelation of changes in amount and type of dietary fat to fecapentaenes in premenopausal women.
Mutat Res
September 1988
Cancer Prevention Studies Branch, NCI, Bethesda, MD 20892.
Correlation studies suggest that fecal mutagenicity is increased in groups eating high-fat diets, the same groups who are often found to have high colorectal cancer incidence and mortality. The fecapentaenes are the best characterized class of fecal mutagens, but the relationship of dietary fat intake to the excretion of these potent genotoxins is unknown. We studied the effect of changes in amount and type of dietary fat on fecapentaene levels in 31 premenopausal women 20-40 years of age who participated in a controlled feeding study.
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