Moderate-to-Vigorous Physical Activity Changes with the Risk of SARS-CoV-2 Infection: A Nested Case-Control Study.

We identified the association of changes in moderate-to-vigorous physical activity (MVPA) with SARS-CoV-2 infection. From 6,396,500 patients, we performed a nested case-control study who participated in both biennial check-ups. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression. From physically inactive patients at period I, the odds increased when engaged in 1-2, 3-4, or ≥5 times of MVPA/week at period II. This study found that MVPA was directly associated with SARS-CoV-2 infection.