AI Article Synopsis
- Effective cellular therapy using CD19 CAR T-cells raises the possibility of administering ACT after transplants to reduce relapse rates and enhance survival in advanced B-cell cancers.
- Early phase clinical studies indicate that tumor-associated antigen-specific T-cells and natural killer cells may benefit high-risk patients post-transplant by decreasing relapse and potentially improving their chances of survival.
- This article reviews the potential of ACT after transplantation to significantly enhance the effectiveness of the transplant procedure and transform the treatment landscape for these malignancies.
Article Abstract
Effective cellular therapy using CD19 chimeric antigen receptor T-cells for the treatment of advanced B-cell malignancies raises the question of whether the administration of adoptive cellular therapy (ACT) posttransplant could reduce relapse and improve survival. Moreover, several early phase clinical studies have shown the potential beneficial effects of administration of tumor-associated antigen-specific T-cells and natural killer cells posttransplant for high-risk patients, aiming to decrease relapse and possibly improve survival. In this article, we present an in-depth review of ACT after transplantation, which has the potential to significantly improve the efficacy of this procedure and revolutionize this field.
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| http://dx.doi.org/10.1002/ajh.27204 | DOI Listing |
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