This study examined domain specificity among 306 high-school students using the (CAAC). The CAAC provides both the quantity of activity and quality of accomplishment scores, allowing an empirical test of possible polymathy among students, some of whom were gifted. Polymathy occurs when an individual performs creatively in more than one domain. This investigation's two objectives were to replicate domain specificity studies with the newest version of the CAAC, which included new domains (i.e., technological and everyday creativity) and quality and quantity scores, and to use it to test for polymathy among students. Previous work with adults suggested that polymaths are creative in multiple domains. They often invest in creative avocations that support their professional creativity. Some evidence of polymathy was uncovered; however, it was not common in this sample. Support for domain specificity was reasonably clear in the present results, yet it was not all-or-nothing but rather a matter of degree. Domains overlapped to varying amount. The amount of overlap varied with the level of talent and from domain to domain. The clearest support for polymathy came from regression analyses which revealed a significant relationship between the quantity of activity in some domains and the quality of creative accomplishment in others. Limitations and future directions are discussed.
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http://dx.doi.org/10.3389/fpsyg.2023.1255508 | DOI Listing |
Hepatology
January 2025
Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Background Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects about a third of adults worldwide and is projected soon to be the leading cause of cirrhosis. It occurs when fat accumulates in hepatocytes and can progress to metabolic dysfunction-associated steatohepatitis (MASH), liver cirrhosis, and hepatocellular carcinoma. MASLD pathogenesis is believed to involve a combination of genetic and environmental risk factors.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO, USA.
Programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) interactions are targets for immunotherapies aimed to reinvigorate T cell function. Recently, it was documented that PD-L1 regulates dendritic cell (DC) migration through intracellular signaling events. In this study, we find that both preclinical murine and clinically available human PD-L1 antibodies limit DC migration.
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January 2025
State Key Lab of Advanced Optical Communication Systems and Networks, Shanghai Jiao Tong University, Shanghai 200240, China.
Holography is capable of rendering three-dimensional scenes with full-depth control and delivering transformative experiences across numerous domains, including virtual and augmented reality, education, and communication. However, traditional holography presents 3D scenes with unnatural defocus and severe speckles due to the limited space bandwidth product of the spatial light modulator (SLM). Here, we introduce Motion Hologram, a holographic technique that accurately portrays photorealistic and speckle-free 3D scenes.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Department of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada 18008, Spain.
Bacterial receptors feed into multiple signal transduction pathways that regulate a variety of cellular processes including gene expression, second messenger levels, and motility. Receptors are typically activated by signal binding to ligand-binding domains (LBDs). Cache domains are omnipresent LBDs found in bacteria, archaea, and eukaryotes, including humans.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Pharmacotherapy, University of Utah, Salt Lake City, Utah, United States of America.
Background: Venous thromboembolism (VTE) and atrial fibrillation (AF) disproportionately affect older adults, who are at increased risk of bleeding from treatment with anticoagulant therapy. The impact of bleeding on older adults' quality of life (QoL) is poorly understood due to the lack of a validated measure of their experience. This study's purpose is to describe the first evidence-based steps in developing a new condition-specific patient-reported outcome measure (PROM) for the effect of anticoagulant-related bleeding on older adults' QoL.
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