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Mushroom tyrosinase enzyme catalysis: synthesis of larvicidal active geranylacetone derivatives against and molecular docking studies. | LitMetric

AI Article Synopsis

Article Abstract

The grindstone process, which uses tyrosinase as a catalyst, was used to create analogues of geranylacetone. Tyrosinase was used to prepare the Mannich base under favourable reaction conditions, resulting in a high yield. All synthesized compounds were characterized using FTIR, Nuclear magnetic resonance, and mass spectral analyses. The active geranylacetone derivatives () were investigated for larvicidal activity against ; compound (LD:20.7 μg/mL) was noticeably more effective than geranylacetone (LD: >100 μg/mL) and permethrin (LD: 24.4 μg/mL) lead compounds because of their ability to kill larvae and use them as pesticides. All compounds were found to be low toxic, whereas compounds , and were screened for antifeedant screening of non -aquatic target for the toxicity measurement against marine fish at 100 μg/mL caused 0% mortality in within 24 h. Molecular docking studies of synthesised compound and permethrin docked with 3OGN, compound demonstrated a greater binding affinity (-9.6 kcal/mol) compared to permethrin (-10.5 kcal/mol). According to these results, the newly synthesised geranylacetone derivatives can serve as lead molecules of larvicides agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806150PMC
http://dx.doi.org/10.3389/fchem.2023.1303479DOI Listing

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