Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1474-4422(24)00002-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
All women with multiple sclerosis should start hormone replacement therapy at menopause unless contraindicated: Yes.
Mult Scler
August 2024
UCLA Department of Neurology, UCLA Multiple Sclerosis Program, UCLA Comprehensive Menopause Care Program, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model.
Front Neurol
November 2023
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Introduction: Multiple sclerosis (MS) affects the cerebral cortex, inducing cortical atrophy and neuronal and synaptic pathology. Despite the fact that women are more susceptible to getting MS, men with MS have worse disability progression. Here, sex differences in neurodegenerative mechanisms are determined in the cerebral cortex using the MS model, chronic experimental autoimmune encephalomyelitis (EAE).
View Article and Find Full Text PDFEstrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice.
Nat Commun
September 2023
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Menopause is associated with cognitive deficits and brain atrophy, but the brain region and cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age interaction whereby loss of ovarian hormones in female mice at midlife, but not young age, induced hippocampal-dependent cognitive impairment, dorsal hippocampal atrophy, and astrocyte and microglia activation with synaptic loss. Selective deletion of estrogen receptor beta (ERβ) in astrocytes, but not neurons, in gonadally intact female mice induced the same brain effects.
View Article and Find Full Text PDFNeuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol.
Lab Invest
August 2023
Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at the University of California, Los Angeles, California; UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California. Electronic address:
In multiple sclerosis (MS), demyelination occurs in the cerebral cortex, and cerebral cortex atrophy correlates with clinical disabilities. Treatments are needed in MS to induce remyelination. Pregnancy is protective in MS.
View Article and Find Full Text PDFChronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis.
Front Mol Neurosci
October 2022
UCLA MS Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Article Synopsis
- Animal models of multiple sclerosis, particularly the experimental autoimmune encephalomyelitis (EAE) model, are key for developing anti-inflammatory treatments for MS.
- The chronic EAE model in C57BL/6 mice, induced by myelin oligodendrocyte glycoprotein (MOG) peptide 35-55, shows similar neuropathological features to MS, including white matter lesions and widespread damage in various brain regions.
- This review suggests that the chronic EAE model is an effective tool for studying neuroaxonal degeneration associated with multiple sclerosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!