Researchers have long interpreted the presence or absence of semantic interference in picture naming latencies as confirming or refuting theoretical claims regarding competitive lexical selection. But inconsistent empirical results challenge any mechanistic interpretation. A behavioral experiment first verified an apparent boundary condition in a blocked picture naming task: when orthogonally manipulating association type, taxonomic associations consistently elicit interference, while thematic associations do not. A plausible representational difference is that thematic feature activations depend more on supporting contexts. Simulations show that context-sensitivity emerges from the distributional statistics that are often used to measure thematic associations: residual semantic activation facilitates the retrieval of words that share semantic features, counteracting learning-based interference, and training a production model with greater sequential cooccurrence for thematically related words causes it to acquire stronger residual activation for thematic features. Modulating residual activation, either directly or through training, allows the model to capture gradient values of interference and facilitation, and in every simulation competitive and noncompetitive selection algorithms produce qualitatively equivalent results.
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G3 (Bethesda)
January 2025
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
The mosquito Aedes aegypti is an emerging model insect for invertebrate neurobiology. We detail the application of a dual transgenesis marker system that reports the nature of transgene integration with circular donor template for CRISPR-Cas9-mediated homology-directed repair at target mosquito chemoreceptor genes. Employing this approach, we demonstrate the establishment of cell-type-specific T2A-QF2 driver lines for the A.
View Article and Find Full Text PDFPrevious RNA profiling studies revealed co-expression of overlapping sense/antisense (s/a) transcripts in pro- and eukaryotic organisms. Functional analyses in yeast have shown that certain s/a mRNA/mRNA and mRNA/lncRNA pairs form stable double-stranded RNAs (dsRNAs) that affect transcript stability. Little is known, however, about the genome-wide prevalence of dsRNA formation and its potential functional implications during growth and development in diploid budding yeast.
View Article and Find Full Text PDFEnviron Res
January 2025
College of Ecology and Environment, Anhui Normal University, 189 South of Jiuhua Road, Wuhu, Anhui, 241002, P.R. China; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu, 210023, P.R. China. Electronic address:
The recovery of precious metal ions (PMI) from wastewater has great significances from both economic and environmental perspectives. However, current recovery methods face limitations, including low efficiency and selectivity, as well as challenges in practical applications. In this study, hollow N-doped carbon spheres (HNC) are proved to be promising for improving anionic AuCl and PdCl recovery via the curvature effect, outperforming non-curved carbon (commercial active carbon and carbon nanosheet) due to their unique curvature effect.
View Article and Find Full Text PDFCell Signal
January 2025
Department of Basic Medical Science & Department of Stomatology, School of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address:
Overexpression of integrin β6 (ITGB6) is crucially linked to the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). The molecular mechanisms driving ITGB6 upregulation in HNSCC are not well understood. Our study comprehensively analyzed the transcriptional regulation and epigenetic modification mechanisms affecting ITGB6 transcription.
View Article and Find Full Text PDFTalanta
January 2025
Department of Chemical and Biomolecular Engineering, University of Connecticut, CT, 06269, United States. Electronic address:
This study applies a periodic table-guided approach to select and investigate hafnium oxide (HfO), in conjunction with reduced graphene oxide (rGO), for the electrochemical determination of methyl parathion (MP), an organophosphate insecticide. MP poses significant ecological and health risks due to its high toxicity, and despite bans, illegal use has been reported, especially in the global south. To address these challenges, an electrode modified with a nanocomposite of rGO/HfO was first constructed for MP detection.
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