Organochlorides are a crucial class of electrophiles in organic synthesis. Here, we present a protocol for the cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides, facilitated by an iron/Bpin catalytic system. We describe steps for the coupling of aryl chlorides with alkyl chlorides, followed by purification of products. This protocol can produce alkylated products with up to 81% yield. For complete details on the use and execution of this protocol, please refer to Zhang et al..
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10835013 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2024.102846 | DOI Listing |
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