Switching from oil-based to bio-based feedstocks to ensure the green transition to a sustainable and circular future is one of the most pressing challenges faced by many industries worldwide. For the cosmetics and personal and house care industries there is a strong drive to accelerate this transition from the customers that starts favoring the purchase of naturally derived and bio-degradable products over the traditionally available products. In this work we developed a series of fully biobased macromolecules constituted of a glycerol-based oligoester backbone. Based on the subsequent derivatization with fatty acids or peptides, the resulting products may find application as emulsifiers, wetting agents, and potential vectors for the delivery of bioactive peptides. All steps of the resulting macromolecules were conducted following the green chemistry principles with no toxic or environmentally damaging compounds that were used in the overall production process.
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First site-specific conjugation method for native goat IgG antibodies via glycan remodeling at the conserved Fc region.
Antib Ther
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Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.
Article Synopsis
- Antibody therapies for treating animal diseases, particularly for pain in osteoarthritic cats and dogs, are gaining traction, signaling potential advancements in veterinary medicine.
- Goats are important economically for their milk, meat, and hide, making it essential to develop antibody therapies to protect them, with goat antibodies playing a key role.
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Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, United States.
A versatile chemo-enzymatic tool to site-specifically modify native (nonengineered) antibodies is using transglutaminase (TGase, E.C. 2.
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Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, via Dodecaneso 31, 16146, Genova, Italy.
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