Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigenetics in neurodevelopment, we examined any altered DNA methylation between DLD and control subjects. We looked into genome-wide methylation differences between DLD and control groups. The findings were validated by quantitative PCR (qPCR). In the DLD group, differential methylation of CpG sites was observed in the Wnt signaling regulator genes , , , , , , and . Hypomethylation of , and was confirmed by qPCR. This is the first report associating Wnt signaling with DLD. The findings are relevant in the light of the essential role of Wnt in myelination, and of the altered myelination in DLD.
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