AI Article Synopsis
- The study evaluated the effectiveness of an adapted treatment plan using Ethos™ for patients with pharyngeal cancer undergoing chemoradiotherapy, involving 10 patients with daily cone-beam computed tomography (CBCT) data.
- Simulated treatments were compared over three time periods (early, middle, late) using two different plans: adapted and scheduled, focusing on various dose-volume parameters for the planning target volume (PTV) and organs at risk.
- Results showed that the adapted plan provided better coverage for the PTV and significantly lower doses to the spinal cord and parotid glands compared to the scheduled plan, demonstrating its potential benefits for cancer treatment.
Article Abstract
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959439 | PMC |
| http://dx.doi.org/10.1093/jrr/rrad103 | DOI Listing |
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