AI Article Synopsis
- The study investigates the antimicrobial effects of cold atmospheric plasma (CAP) on bacteria linked to canine bacterial keratitis.
- CAP treatment was tested on multiple bacterial strains from infected dogs, using various treatment durations and distances, demonstrating effective bacterial growth reduction.
- The most successful treatment was a 5-minute application at a 3mm distance, yielding significant inhibition zones, while argon alone did not reduce bacterial growth.
Article Abstract
Purpose: To investigate the antimicrobial effect of cold atmospheric plasma (CAP) on pathogens associated with canine bacterial keratitis.
Materials And Methods: , , and strains, which were obtained from dogs with infectious keratitis, were subjected to testing. For each species, four isolates and a reference strain were cultivated on Columbia sheep blood agar and treated with the kiNPen Vet plasma pen from Neoplas GmbH, Greifswald, Germany. Various continuous treatment durations (0.5, 2, and 5 min) were applied, along with a 0.5-min treatment repeated four times at short intervals. These treatments were conducted at distances of 3 and 18 mm between the agar surface and the pen.
Results: CAP treatment reduced bacterial growth in all three species. The most effective treatment duration was 5 min at 3 mm distance, resulting in inhibition zones ranging from 19 to 22 mm for , 26-45 mm for and an overall reduction of bacterial growth for . Inhibition zones were smaller with decreasing treatment duration and larger distance. Treatment times of 30 s repeated four times and 2 min showed comparable results. Treatment with argon alone did not lead to visible reduction of bacterial growth.
Conclusion: Argon cold atmospheric plasma demonstrated a potent antimicrobial effect on and strains with the latter showing the highest sensitivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803497 | PMC |
| http://dx.doi.org/10.3389/fvets.2023.1320145 | DOI Listing |
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