AI Article Synopsis
- The study focused on gene mutations in breast cancer patients from Zhoushan Islands and their connection to various clinical features.
- High-throughput gene sequencing was conducted on 776 patients, revealing a 4.38% mutation rate, particularly linked to age, molecular type, and family history.
- Invasive lobular carcinoma showed the highest mutation rates, especially among patients with the luminal B type of breast cancer.
Article Abstract
Objective: To investigate / gene mutations and their relationship with clinicopathological features in patients with breast cancer in Zhoushan Islands.
Methods: High-throughput whole-exome gene sequencing was used to detect / mutations in 776 breast cancer patients in Zhoushan Islands.
Results: The / mutation rate of breast cancer patients in Zhoushan Islands was 4.38% (34/776). mutations were significantly correlated with age, molecular type, and family history of breast and ovarian cancers. mutations were most commonly found in invasive lobular carcinoma. Moreover, the mutation rate of cancers with molecular type luminal B (receptor protein-tyrosine kinase [HER2]-negative) was also relatively high.
Conclusion: The rate of / mutations in breast cancer patients from Zhoushan Islands is approximately 4.38%, and mutation is related to age, molecular type, and family history of breast and ovarian cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807394 | PMC |
| http://dx.doi.org/10.1177/03000605231223426 | DOI Listing |
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