AI Article Synopsis
- * Researchers identified 19 genes linked to PD through gene regulatory networks and Mendelian Randomization, revealing connections between these genes and common traits associated with the disease.
- * The study suggests that while different genes affect PD risk and symptoms, overlapping pathways may increase the risk and symptom variability in patients, offering potential targets for new treatments.
Article Abstract
Understanding the biological mechanisms that underlie the non-motor symptoms of Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex interplay of genetic risk factors. Here, we used a disease-agnostic brain cortex gene regulatory network integrated with Mendelian Randomization analyses that identified 19 genes whose changes in expression were causally linked to PD. We further used the network to identify genes that are regulated by PD-associated genome-wide association study (GWAS) SNPs. Extended protein interaction networks derived from PD-risk genes and PD-associated SNPs identified convergent impacts on biological pathways and phenotypes, connecting PD with established co-occurring traits, including non-motor symptoms. These findings hold promise for therapeutic development. In conclusion, while distinct sets of genes likely influence PD risk and outcomes, the existence of genes in common and intersecting pathways associated with other traits suggests that they may contribute to both increased PD risk and symptom heterogeneity observed in people with Parkinson's.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10805842 | PMC |
| http://dx.doi.org/10.1038/s41531-024-00638-w | DOI Listing |
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